Abstract: In order to improve the physical properties, hemostatic and wound healing functions of the chitosan sponges, this paper prepared chitosan porous sponges via physically quick-foaming and freezedrying method. And took sodium alginate as the macromolecular crosslinking agent. Results indicated that the macromolecular crosslinking agent was non-toxic, and the mechanical properties and absorbency of the crosslinked chitosan bio sponge were remarkably improved. It has been further proved by hemostasis test and in vivo degradation test that hemostatic sponge has rapid hemostasis efficiency and excellent biocompatibility, and has broad application prospects in medical materials.

Key words: chitosan; crosslinking; freeze-drying; hemostatic sponges; biocompatibility